糖尿病腎病是糖尿病主要的慢性微血管并發(fā)癥之一，也是引起終末期腎病最常見的原因。糖尿病腎病代謝組學(xué)通過研究內(nèi)源性代謝物產(chǎn)生的變化性和規(guī)律性，尋找新的診斷指標(biāo)，并為糖尿病腎病的早期診斷和機(jī)制研究提供了新思路。綜述近十年來糖尿病腎病代謝組學(xué)的差異代謝物研究現(xiàn)狀，并從差異代謝物的檢出頻次、樣本分布、類別及生物學(xué)意義方面進(jìn)行了深入分析，以期促進(jìn)糖尿病腎病病理機(jī)制更廣泛而深入的研究。

Diabetic Kidney Disease is one of most common chronic microvascular complications of diabetes mellitus. It is the leading pathogency of end-stage of renal disease and the main death cause of diabetes mellitus. Metabolomics of diabetic kidney disease were to look for new detection targets and establish new identification technology by studying the regularity and characteristic of the endogenous small molecule metabolisms. we conducted a systematic search using the key terms of ‘metabolomics’ and ‘metabonomics’ with ‘diabetic kidney disease’. Finally we selected 39 articles. These researches help us to find more sensitive biomarkers to contribute to the diagnosis and therapeutic treatment of DKD at an early phase and provide some ideas for the research of DKD. This systematic review mainly summarized the current state of research on differential biomarkers of DKD and discussed the clinical relevance of metabolomics in the prediction, diagnosis and management of DKD.

國家自然科學(xué)基金（81774014）