藥物轉(zhuǎn)運(yùn)體在中藥及單體成分的體內(nèi)吸收、分布和排泄過程中發(fā)揮著重要的作用。中藥及單體對(duì)藥物轉(zhuǎn)運(yùn)體的功能和表達(dá)可產(chǎn)生誘導(dǎo)或抑制作用，從而影響這些轉(zhuǎn)運(yùn)體底物的體內(nèi)處置過程。隨著中藥藥動(dòng)學(xué)的發(fā)展，基于轉(zhuǎn)運(yùn)體介導(dǎo)的中藥及單體體內(nèi)處置研究越來越受到重視。該文對(duì)藥物轉(zhuǎn)運(yùn)體介導(dǎo)的中藥及單體藥動(dòng)學(xué)的研究進(jìn)行綜述。

Drug transporters play an important role in the absorption, distribution and excretion of traditional Chinese medicine (TCM) and monomers in vivo. TCM and monomers can induce or inhibit the function and expression of drug transporters, thus affecting the disposal of substratesin vivo. With the development of pharmacokinetics of TCM, drug transporters mediated TCM and monomer disposal in vivohave been more and more reported. In this review, we reviewed the research on drug transporters mediated pharmacokinetics of TCM and monomers.