天然藥物包括植物藥、動物藥和海洋藥物，在我國天然植物藥的使用有悠久的歷史。但是隨著現(xiàn)代科學(xué)技術(shù)的發(fā)展，馬兜鈴酸腎病的發(fā)現(xiàn)，人們逐漸對天然植物藥的安全性產(chǎn)生了懷疑。此后多年，陸續(xù)從天然植物藥中分離了多種有肝腎毒性的化合物。重點圍繞已知的化合物代謝形成DNA加合物的過程闡述天然植物藥致突變致癌分子機制的研究進展。

Natural medicines include botanicals, animal medicines and marine medicines. In China, there is a long history of the use of natural botanicals. However, with the development of modern science and technology, the discovery of aristolochic acid nephropathy, people have gradually doubted the safety of natural botanical drugs. Since then, many compounds with liver and kidney toxicity have been isolated from natural botanicals. This paper focuses on the research progress of molecular mechanisms of mutagenic carcinogenesis of natural botanicals by the process of known compound metabolism in the form of DNA adducts.