腫瘤細(xì)胞的代謝重編程被認(rèn)為是腫瘤的十大特征之一。腫瘤組織通過代謝重編程以滿足腫瘤快速生長(zhǎng)對(duì)生物能量、生物合成和氧化還原的需求。伴隨著腫瘤代謝重編程，細(xì)胞內(nèi)外的一些代謝產(chǎn)物對(duì)基因表達(dá)、細(xì)胞分化和腫瘤微環(huán)境均具有深遠(yuǎn)的影響。其中最顯著的變化包括糖酵解的激活、脂質(zhì)代謝的增加、線粒體生物合成增強(qiáng)以及磷酸戊糖通路的激活。代謝重編程不僅發(fā)生在正常細(xì)胞向腫瘤細(xì)胞轉(zhuǎn)化的過程中，也發(fā)生在晚期腫瘤細(xì)胞的發(fā)育過程中，與抗癌藥物的敏感性有很密切的關(guān)系。因此，化療藥物聯(lián)合細(xì)胞代謝抑制劑可能是一種有望克服腫瘤耐藥的策略。從這個(gè)角度討論腫瘤細(xì)胞代謝與腫瘤耐藥的關(guān)系，并總結(jié)出失調(diào)的代謝通路可以作為潛在的腫瘤治療靶點(diǎn)，來抑制對(duì)常規(guī)治療耐藥的腫瘤。

Metabolic reprogramming of tumor cells is considered to be one of the ten features of tumors.It usually occurs in tumor tissues to meet the bioenergy,biosynthesis,and redox requirements for the rapid proliferation of tumors.With the reprogramming of tumor metabolism,some intracellular or extracellular metabolites have profound effects on gene expression,cell differentiation and tumor microenvironment.At the same time,tumor metabolism is also closely related to chemotherapy resistance.This review discusses the relationship between metabolism and chemoresistance,and we conclude that dysregulated metabolic pathways can be used as a potential therapeutic target to suppress the tumors that are resistant to conventional treatment.

國家自然科學(xué)基金項(xiàng)目（81573496，81773989）