目的 探討醋酸曲普瑞林對體外受精-胚胎移植（IVF-ET）激素替代周期治療患者子宮內(nèi)膜及性激素的影響。方法 選取2015年1月-2017年1月接受IVF-ET治療的患者100例，根據(jù)隨機數(shù)字表法分為對照組與觀察組，各50例。對照組單純采取激素替代周期，觀察組在激素替代周期治療基礎(chǔ)上使用醋酸曲普瑞林，對比兩組治療前及治療后血清性激素水平，比較兩組子宮內(nèi)膜厚度、內(nèi)膜轉(zhuǎn)換時間及妊娠結(jié)局。結(jié)果 治療后，兩組子宮內(nèi)膜厚度均增厚（P<0.05）；觀察組子宮內(nèi)膜厚度厚于對照組，內(nèi)膜轉(zhuǎn)換時間短于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。兩組患者基礎(chǔ)血清性激素水平比較，差異無統(tǒng)計學(xué)意義；治療后，兩組促黃體生成素（LH）、卵泡刺激素（FSH）、雌二醇（E2）、睪酮（T）水平降低，孕酮（P）、泌乳素（PRL）水平升高，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；治療后，兩組患者LH、FSH、PRL、P、T水平比較，差異無統(tǒng)計學(xué)意義；觀察組E2水平低于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。兩組患者胚胎種植率、早期流產(chǎn)率比較，差異無統(tǒng)計學(xué)意義；觀察組臨床妊娠率高于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 醋酸曲普瑞林聯(lián)合激素替代周期在胚胎著床及臨床妊娠方面較單純激素替代周期方案效果更理想，患者血清雌二醇水平明顯改善，子宮內(nèi)膜厚度增加，聯(lián)合方案并不會增高患者早期流產(chǎn)率。

Objective To investigate the effect of triptorelin acetate combined with hormone replace treatment on endometrium and sex hormone level in patients with in vitro fertilization and embryo transfer (IVF-ET),and to provide reasonable reference for future treatment of IVF-ET.Methods 100 patients with IVF-ET treatment in our hospital from January 2015 to January 2017 were selected,and they were divided into control group and observation group by random number table,with 50 cases in each group.Control group was purely given hormone replace treatment,while observation group was treated with triptorelin acetate based on control group.The basic serum sex hormone and falling 14 d serum sex hormone levels were compared between the two groups.The endometrial thickness and endometrial conversion time,pregnancy outcome of two groups were compared.Results The endometrial thickness of observation group was thicker than that of control group,and the endometrial conversion time was shorter than control group (P< 0.05).There was no statistical difference in the basic serum sex hormone levels between the two groups.In the falling of 14d,there was no statistical difference in the levels of luteinizing hormone (LH),follicle stimulating hormone (FSH),prolaction (PRL),progesterone (P),testosterone (T) between the two groups.The levels of estradiol (E2) in observation group was lower than that in control group (P< 0.05).There was no statistical difference in the embryo implantation rate and first trimester abortion rate between the two groups.The clinical pregnancy rate of observation group was higher than that of control group (P< 0.05).Conclusion Triptorelin acetate combined with hormone replace treatment is more effective in embryo implantation and clinical pregnancy than pure hormone replace treatment,which can improve estradiol level and increase endometrial thickness.The combined therapy will not increase the first trimester abortion rate,and it has satisfactory safety.