目的 探討復(fù)方丹參注射液聯(lián)合奧拉西坦對血管性癡呆患者中醫(yī)證候及炎癥因子的影響。方法 對南陽市精神病醫(yī)院2016年1月-2017年12月63例血管性癡呆患者的臨床資料進(jìn)行回顧性研究，根據(jù)不同的給藥方案將其分為對照組31例和觀察組32例，對照組患者給予奧拉西坦治療，觀察組患者在對照組的基礎(chǔ)上聯(lián)合復(fù)方丹參注射液治療，均持續(xù)治療1個月。比較兩組患者的臨床療效、治療前后的中醫(yī)證候、認(rèn)知功能、日常生活自理能力及血清炎性因子水平變化。結(jié)果 觀察組患者治療總有效率為96.38%，對照組患者治療總有效率為80.65%，兩組比較差異顯著（P<0.05）。治療后兩組患者各中醫(yī)證候評分較治療前均明顯降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組優(yōu)于對照組，兩組比較差異顯著（P<0.05）。治療后兩組MMSE及ADL評分較治療前均明顯降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組優(yōu)于對照組，兩組比較差異顯著（P<0.05）。治療后兩組患者各炎癥因子水平較治療前均明顯降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組優(yōu)于對照組，兩組比較差異顯著（P<0.05）。結(jié)論 復(fù)方丹參注射液聯(lián)合奧拉西坦可有效改善患者的中醫(yī)證候及認(rèn)知功能，抑制機(jī)體炎癥反應(yīng)，提高日常生活自理能力，療效確切，在血管性癡呆的治療中具有重要應(yīng)用意義。

Objective To explore influence of compound danshen injection combined with oxiracetam on TCM syndrome and inflammatory factor in the treatment of vascular dementia.Methods The clinical data of 63 patients with vascular dementia were retrospectively studied from January 2016 to December 2017.According to different dosing regimens,all patients were divided into control group of 31 cases and study group of 32 cases.The study group was treated with oxiracetam,the experimental group on the basis of this combination of compound danshen injection.The clinical effect,TCM syndrome,cognitive function,self-care ability of daily life and serum inflammatory factor level changing before and after treatment between two groups were compared.Results The total effective rate in the experimental group were significant higher than in the control group (96.38% vs 80.65%)(P< 0.05).After treatment,TCM syndrome score,MMSE score,ADLscore and inflammatory factor level of the two groups were significantly reduced than before treatment (P< 0.05),and the experimental group were obviously better than the control group,and there was significant difference (P< 0.05).Conclusions Compound danshen injection combined with oxiracetam in the treatment of vascular dementia can effectively improve on TCM syndrome and cognitive function,inhibit the body inflammatory response,increase selfcare ability of daily life,the exact effect,which has improtant value.