目的 探討普羅布考在治療非增殖型糖尿病視網(wǎng)膜病變合并高血脂患者的臨床效果，分析普羅布考的應(yīng)用價(jià)值。方法 選擇要求為明確診斷為非增殖型糖尿病視網(wǎng)膜病變且有高血脂的患者，62例患者根據(jù)隨機(jī)抽簽原則分為對(duì)照組和觀察組，對(duì)照組26例患者給予降血糖、眼部對(duì)癥治療，而觀察組36例患者則在降血糖、對(duì)癥治療的同時(shí)服用普羅布考，用量為3片/次，2次/d。兩組均治療6個(gè)月。觀察比較兩組患者血脂指標(biāo)、眼底指標(biāo)和抗氧化指標(biāo)的改善情況，比較兩組療效。結(jié)果 兩組均能有效的降低血糖及糖化血紅蛋白，與治療前相比差異顯著，具有統(tǒng)計(jì)學(xué)意義（P<0.05），但兩組對(duì)比則差異不明顯。經(jīng)過6個(gè)月的治療后，觀察組患者的超氧化物歧化酶（SOD）和T總抗氧化能力（AOC）顯著上升，而丙二醛（MDA）下降，相對(duì)于治療前差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；對(duì)照組患者治療前后的差異較小，氧化應(yīng)激指標(biāo)的變化無統(tǒng)計(jì)學(xué)意義；治療后兩組氧化應(yīng)激指標(biāo)差異明顯，具有統(tǒng)計(jì)學(xué)意義（P<0.05）。觀察組能夠有效的改善眼底情況，有效率高達(dá)68.06%，而對(duì)照組僅有38.46%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。普羅布考對(duì)非增殖型糖尿病視網(wǎng)膜病變患者的視力有很明顯的提高作用，經(jīng)過6個(gè)月的治療，觀察組有效率為75.00%，明顯高于對(duì)照組的44.23%，差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。觀察組患者的血脂改善情況顯著，而對(duì)照組基本無改變，對(duì)比治療后兩組的血脂情況可知，差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 良好的控制血脂作用和抗氧化能力是普羅布考作用價(jià)值的體現(xiàn)，有利于提高患者的使用體驗(yàn)、治療效果和滿意度。

Objective To investigate the clinical effect of the probucol for patients with high blood lipid and non proliferative diabetic retinopathy.Methods 62 patients were selected,26 cases were symptomatic treatment,and the remaining 36 cases patients were taking probucol at the same time,the above patients were divided into routine group and drug group.Observed the improvement of systemic symptoms and ocular symptoms in each group.Results Systemic symptoms of patients in the drug group improved significantly,malondialdehyde decreased were significantly higher than those in the routine group,the rise in drug group patients with antioxidant indexes were significantly better than the routine group (P< 0.05).For the eye index after probucol therapy in patients,effectively improved the vision at the same time,could effectively change the fundus and retinal lesions,promoted the average distribution of retinal blood vessels,improved visual function,reduce macular edema,compared with normal group,the differences were statistically significant (P< 0.05).Conclusion Probucol can reduce high blood lipid and Ocular fundus diseases caused by diabetes treatment.