目的 探討雪梨止咳糖漿合孟魯司特鈉對小兒咳嗽變異性哮喘的療效及安全性。方法 選擇安陽市婦幼保健院2015年1月-2018年1月收治的81例咳嗽變異性哮喘患兒，根據(jù)隨機(jī)數(shù)字表法分為觀察組（39例）及對照組（42例），對照組患兒給予孟魯司特鈉，觀察組在對照組基礎(chǔ)上給予雪梨止咳糖漿，兩組治療療程均為1個(gè)月。對比兩組患兒的臨床療效，治療前后的咳嗽、喘息、咳痰、哮鳴音、胸膈滿悶積分，治療前后的用力呼氣流量（FEF）取25%、50%肺活量呼氣流速占預(yù)計(jì)值的百分比及血清IgE水平，治療期間兩組的不良反應(yīng)。結(jié)果 觀察組總有效率為97.44%，明顯高于對照組的80.95%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組的咳嗽、喘息、咳痰、哮鳴音、胸膈滿悶評分均明顯降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組明顯低于對照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組FEF25%、FEF50%均明顯升高，IgE水平明顯降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組FEF25%、FEF50%明顯高于對照組，而IgE水平明顯低于對照組，組間差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組的不良反應(yīng)組間對比無統(tǒng)計(jì)學(xué)意義。結(jié)論 孟魯司特鈉聯(lián)合雪梨止咳糖漿治療小兒咳嗽變異性哮喘安全有效，值得臨床推廣應(yīng)用。

Objective To investigate the efficacy and safety of Xueli Zhike Tangjiang combined with monteluk sodium in children with cough variant asthma.Methods 81 cases with cough variant asthma from Jan.2015 to Jan.2018 in our hospital were chosen and divided into the observation group (39 cases) and control group (42 cases),the control group were given monteluk sodium,the observation group were given Xueli Zhike Tangjiang on the base of control group,the clinical efficacy,the cough,wheezing,coughing,wheezing,and chest fullness before and after treatment,the FEF25%,FEF50% and IgE level in serum before and after treatment in two groups were compared,the adverse reaction of two groups were compared.Results The total effective rate was 97.44% in the observation group,which was significantly higher than 80.95 in the control group (P< 0.05).After treatment,the scores of cough,wheezing,expectoration,wheezing and chest diaphragm fullness in the two groups were significantly lower than those in the control group (P< 0.05),and those in the observation group were significantly lower than those in the control group (P< 0.05).After treatment,the levels of FEF 25% and FEF 50% in both groups were significantly increased,and IgE levels were significantly decreased.There was significant difference before and after treatment in the same group (P< 0.05).The levels of FEF25% and FEF50% in the observation group were significantly higher than those in the control group,while the levels of IgE were significantly lower than those in the control group (P< 0.05).There was no significant difference in adverse reactions between the two groups.Conclusion Xueli Zhike Tangjiang combined with montelukast sodium was safe and effective in treatment of cough variant asthma in children,which was worthy of clinical application.