目的 研究酚妥拉明聯(lián)合亞胺培南西司他丁治療重癥新生兒肺炎的療效。方法 選擇2015年1月-2017年12月駐馬店市中心醫(yī)院收治的108例重癥新生兒肺炎患者，隨機(jī)分為兩組。對照組單獨(dú)采用亞胺培南西司他丁治療，每次0.5 g，每6 h給藥1次；觀察組在對照組基礎(chǔ)上聯(lián)合給予酚妥拉明0.2 mg/kg，每天給藥2次。兩組均治療5 d。比較兩組的癥狀改善情況、血清炎癥因子和肺功能的改變情況。結(jié)果 與對照組有效率74.07%比較，觀察組有效率88.89%明顯提高，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。觀察組的體溫恢復(fù)正常時(shí)間、每天吸痰次數(shù)以及肺部啰音消失時(shí)間明顯低于對照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組治療后的血清C反應(yīng)蛋白（CRP）、白介素-4（IL-4）以及白介素-6（IL-6）水平均明顯降低，白介素-10（IL-10）水平明顯升高，同組治療前后比較差異均有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組明顯優(yōu)于對照組，組間差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組治療后的第一秒最大呼氣量（FEV1）、用力肺活量（FVC）、用力呼氣25%流速（MEF25）、最大呼氣流速峰值（PEF）及用力呼氣50%流速（MWV50）均明顯升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組以上指標(biāo)明顯高于對照組，組間差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 酚妥拉明聯(lián)合亞胺培南西司他丁治療重癥新生兒肺炎的效果較為確切，值得應(yīng)用推廣。

Objective To investigate the effect of phentolamine combined with imiminosinastatin in the treatment of severe neonatal pneumonia.Methods Selected 108 cases of patients with severe neonatal pneumonia who were treated in our hospital from January 2015 to December 2017,divided into two groups randomly.The control group was treated with imiminosinastatin and the observation group was given phentolamine.Symptom improvement,serum inflammatory factors and lung function were compared between the two groups.Results The effective rate of the observation group was significantly higher than control group (P< 0.05).The recovery time of body temperature,the frequency of sputum aspiration and the time of pulmonary rales disappeared in the observation group were significantly lower than those in the control group (P< 0.05).The average levels of serum CRP,IL-4 and IL-6 in the two groups were significantly decreased (P< 0.05),and the level of IL-10 increased significantly (P< 0.05),and the observation group was more significant (P< 0.05).FEV1,FVC,MEF25,PEF and MWV50 in the two groups were significantly increased (P< 0.05),and the observation group was more significant (P< 0.05).Conclusion Phentolamine combined with imipenem cilastatin in the treatment of severe neonatal pneumonia is more effective,worthy of application and promotion.