苦參堿類生物堿具有廣泛的生物活性，如保護心、肝、肺、腎、腦、血管作用，對心臟有正性肌力、負性頻率、抗心律失常作用，還有升高白細胞，平喘，抗?jié)?，抗肝纖維化以及鎮(zhèn)靜、催眠、鎮(zhèn)痛等中樞神經(jīng)藥理作用，也具有抗腫瘤、免疫調(diào)節(jié)、抗菌、抗病毒、抗炎等藥理作用?？鄥A類生物堿對機體免疫功能具有雙向調(diào)節(jié)作用，在高劑量時表現(xiàn)為免疫抑制作用，在低劑量時表現(xiàn)為免疫促進作用。綜述氧化苦參堿、苦參堿、槐定堿和槐果堿的免疫促進作用，為進一步開發(fā)研究和臨床應(yīng)用提供參考。

Matrine-type alkaloids have awidespread bioactivities,including protection of heart,liver,lung,kidney,brain and blood vessel,andtheeffectsofpositiveinotropism,negativechronotropismandantiarrhythmiaonheart,andpromotingleukocytes,antiasthma,antiulcer,anti-fibrogenesisinliver,andcentralsuppressionofsedation,hypnogenesis,analgesia,andantitumor,immunoregulation,anti-bacteria,antivirus and anti-inflammation effect.Matrine-type alkaloids have two-way immunoregulation.Matrine-type alkaloids show immunosuppressant effects in high dosage,and immunostimulant effects in low dosage.The literatures on immunostimulation of oxymatrine,matrine,sophoridine,sophocarpine have been reviewed for the development research and clinical use.