雙膦酸鹽類(lèi)藥物用于預(yù)防與治療骨吸收相關(guān)疾病，包括第1代的依替膦酸二鈉、替魯膦酸二鈉、氯膦酸二鈉，第2代的帕米膦酸二鈉、阿侖膦酸鈉，第3代的利塞膦酸鈉、伊班膦酸鈉、唑來(lái)膦酸等。該類(lèi)藥物口服達(dá)峰時(shí)間較短，吸收率偏低，生物利用度很低；骨結(jié)合部分的半衰期較長(zhǎng)，藥物留存時(shí)間也較長(zhǎng)。與雙膦酸鹽聯(lián)用產(chǎn)生相互作用的藥物主要為：含有二價(jià)陽(yáng)離子藥物、其他雙膦酸鹽藥物、華法林、苯妥英、非甾體類(lèi)抗炎藥、抗癌藥、激素、H2受體拮抗劑以及腎毒性藥物。從藥動(dòng)學(xué)角度解釋雙膦酸的藥物相互作用，以避免不良反應(yīng)發(fā)生。

Bisphosphonates including the first generation of etidronate disodium,tiludronate disodium and clodronate disodium,the second generation of pamidronate and alendronate,the third generation of risedronate sodium,ibandronate and zoledronic acid,and etc,are used to prevent and treat bone resorption diseases.The oral bisphosphonates have short t_max,low absorption rate and low bioavailability.The half-life and drug retention time of the bone-binding part is long.The drugs that interact with bisphosphonates are mainly:divalent cation-containing drugs,other bisphosphonate drugs,warfarin,phenytoin,non-steroidal anti-inflammatory drugs,anticancer drugs,hormones,H2 receptor antagonists and nephrotoxic drugs.The drug interactions of bisphosphonates can be explained from the perspective of pharmacokinetics to avoid adverse drug reactions.