目的 建立山楂紅曲膠囊中洛伐他汀的處理及含量測定方法。方法 色譜柱為Kromasil C₁₈柱（250 mm×4.6 mm，5μm），紫外檢測波長238 nm，柱溫25℃，體積流量1.0 mL/min，流動(dòng)相為甲醇：0.1%磷酸溶液（75：25）。結(jié)果 洛伐他汀質(zhì)量濃度在2.04~306 μg/mL與峰面積線性關(guān)系良好，平均回收率為98.58%，RSD=1.12%（n=9）。結(jié)論 該方法準(zhǔn)確、簡便，可用于山楂紅曲膠囊的質(zhì)量控制。

Objective To establish a method of processing and determining for the lovastatin in Monascus Capsules.Methods Inspecting the influence of water bath temperature to the transformation of lovastatin structure,on the basis of "content determination standards for lovastatin in the health food".Chromatographic separation was achieved on a Kromasil C₁₈ analytical column (250 mm×4.6 mm,5 μm),and the detection wavelength was set at 238 nm,maintained at 25℃.The prepared mobile phase was delivered at a flow rate of 1.0 mL/min.The mobile phase consisted of 75% Methano and 25% Phosphoric acid (0.1%).Results the linear range was 2.04 to 306 μg/mL.The average recovery was 98.58%.The precision was 1.12%(n=9).Conclusion The improved method for determination is that transforming acid structure of lovastatin into lactone structure,the method which is accurate and simple can be applied to control the quality of Monascus Capsules.