目的 探討麥角新堿聯(lián)合卡前列素氨丁三醇預防和治療宮縮乏力性產(chǎn)后出血的臨床效果。方法 選取2015年5月-2018年5月入住河南科技大學第一附屬醫(yī)院的82例宮縮乏力性產(chǎn)后出血患者，隨機分為觀察組（n=41）和對照組（n=41）。對照組宮體注射卡前列素氨丁三醇250 μg；觀察組在對照組基礎(chǔ)上肌內(nèi)注射麥角新堿0.2 mg。對比兩組臨床療效、產(chǎn)后出血量、血紅蛋白含量和凝血功能。結(jié)果 與對照組總有效率73.17%比較，觀察組總有效率97.56%顯著升高（P<0.05）。兩組產(chǎn)后2 h出血量比較，差異無統(tǒng)計學意義。觀察組產(chǎn)后2~24 h及產(chǎn)后24 h出血量均顯著少于對照組（P<0.05），且血紅蛋白含量顯著高于對照組（P<0.05）。產(chǎn)后2 h兩組纖維蛋白原（FIB）和D-二聚體（D-D）均顯著低于產(chǎn)前（P<0.05）；且觀察組凝血酶原時間（PT）、凝血酶時間（TT）均顯著高于對照組（P<0.05），F(xiàn)IB和D-D均顯著低于對照組（P<0.05）。結(jié)論 麥角新堿聯(lián)合卡前列素氨丁三醇預防和治療宮縮乏力性產(chǎn)后出血的效果顯著，值得臨床推廣。

Objective To investigate the clinical effect of ergometrine combined with romethamine in the prevention and treatment of postpartum hemorrhage caused by uterine inertia.Methods 82 cases of postpartum hemorrhage caused by uterine inertia admitted to our hospital from May 2015 to May 2018 were randomly divided into observation group (ergometrine+romethamine,n=41) and control group (romethamine,n=41).The clinical efficacy,postpartum hemorrhage,hemoglobin content and coagulation function were compared between the two groups.Results The total effective rate of the observation group was 97.56%(40/41) higher than that of the control group[73.17%(30/41)](P<0.05).There was no significant difference in the amount of 2h bleeding between the two groups.The amount of bleeding in the observation group was significantly less than that in the control group (P<0.05),and the content of hemoglobin was significantly higher than that in the control group (P<0.05).FIB and D-D were significantly lower in both groups 2 hours after delivery (P<0.05),PT and TT in observation group were significantly higher than those in control group (P<0.05),FIB and D-D were significantly lower than those in control group (P<0.05).Conclusion Ergometrine combined with romethamine is effective in preventing and treating postpartum hemorrhage caused by uterine inertia,and is worthy of clinical promotion.