目的 探討丁苯酞注射液對急性大腦中動脈供血區(qū)卒中患者的療效及對腦血管CO₂反應性（CO₂R）的影響。方法 選擇2014年1月-2017年8月在河南大學附屬南陽南石醫(yī)院神經(jīng)內科診治的119例急性大腦中動脈供血區(qū)卒中患者，根據(jù)治療方法的不同分為觀察組69例與對照組50例。對照組采用常規(guī)藥物治療，觀察組在對照組基礎上聯(lián)合丁苯酞注射液治療，兩組治療觀察28 d。比較兩組臨床療效、簡明智力狀態(tài)檢查量表（MMSE）評分、腦梗死體積及腦血管CO₂R變化情況。結果 觀察組的總有效率為99.55%，顯著高于對照組的88.00%（P<0.05）。治療后兩組的腦梗死體積都較治療前顯著下降（P<0.05），且觀察組顯著低于對照組（P<0.05）。兩組治療后的MMSE評分都顯著高于治療前（P<0.05），且觀察組顯著高于對照組（P<0.05）。治療后兩組的屏氣指數(shù)都顯著高于治療前（P<0.05），且觀察組顯著高于對照組（P<0.05）。結論 丁苯酞注射液在急性大腦中動脈供血區(qū)卒中患者中的應用能改善腦血管CO₂R狀況，提高治療效果與縮小腦梗死體積，促進認知功能的恢復。

Objective To explore the effect of butylphthalide Injection on cerebral vascular CO₂ reaction (CO₂R) in patients with acute middle cerebral artery blood supply area stroke.Methods From January 2014 to August 2017,119 patients with acute middle cerebral artery blood supply area stroke were selected and were divided into the 69 patients in the observation group and the 50 patients of the control group accorded to the different treatment methods,the control group were treated with conventional drugs,the observation group were treated with Butylphthalide Injection on the basis of the control group,and the two groups were treated with 28 d.The changes of CO₂R in cerebral vessels were recorded.Results All the patients were completed the treatment.The total effective rates of the observation group and the control group were 92.8% and 60%,respectively,and the observation group were significantly higher than the control group (P<0.05).After treatment,the volume of cerebral infarction in the two groups were decreased significantly (P<0.05),and the decreased values in the observation group were significantly more than that in the control group (P<0.05).After treatment,the MMSE scores of the two groups were significantly higher than those before treatment,and the score of the observation group were also higher than that of the control group after treatment (P<0.05).After treatment,the breath holding index of the observation group and the control group were significantly higher than those before treatment (P<0.05),and the observation group were also higher than that of the control group (P<0.05).Conclusion The application of Butylphthalide Injection in stroke patients with acute middle cerebral artery blood supply area stroke can improve the status of cerebral vascular CO₂R,improve the therapeutic effect and reduce the volume of cerebral infarction,and promote the recovery of cognitive function.