目的 探討血必凈聯(lián)合多巴胺、酚妥拉明對(duì)慢性阻塞性肺疾病（COPD）急性加重期合并多臟器功能衰竭患者預(yù)后的影響。方法 選取2015年6月-2018年6月安陽市第二人民醫(yī)院80例COPD急性加重期并多臟器功能衰竭患者為研究對(duì)象，根據(jù)不同給藥方法將入選者分為對(duì)照組和觀察組，每組40例，對(duì)照組給予多巴胺+酚妥拉明，觀察組在對(duì)照組基礎(chǔ)上給予血必凈注射液，連續(xù)治療2周。比較兩組患者的治療總有效率，治療前后各血?dú)庵笜?biāo)、凝血功能指標(biāo)及炎癥因子水平變化。結(jié)果 觀察組治療總有效率（92.50%）顯著高于對(duì)照組（77.50%），差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后兩組患者各血?dú)庵笜?biāo)及凝血功能指標(biāo)較治療前均明顯改善，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組顯著優(yōu)于對(duì)照組，組間差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后兩組患者各炎癥因子水平較治療前均顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組低于對(duì)照組，組間差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 血必凈聯(lián)合多巴胺、酚妥拉明可有效改善患者的血?dú)庵笜?biāo)及凝血功能指標(biāo)，抑制機(jī)體炎性反應(yīng)，降低病死率，值得在COPD急性加重期并多臟器功能衰竭患者的治療中應(yīng)用推廣。

Objective To explore effect of Xuebijing combined with dopamine and phentolamine on prognosis of patients with acute exacerbation of COPD and multiple organ failure.Methods 80 patients with acute exacerbation of COPD and multiple organ failure were selected as the subjects from June 2015 to June 2018.According to different administration methods,all patients were divided into control group (dopamine+phentolamine) and study group (dopamine+phentolamine+Xuebijing) with 40 cases in each group.Total treatment efficiency,blood gas index,coagulation function index and inflammatory factor level changes before and after treatment were compared the two groups.Results The total effective rate in the study group was significantly higher than that in the control group (P<0.05).After treatment,the gas and blood and coagulation function indexes in the two groups were significantly reduced than those before treatment,and the study group was significantly better than the control group (P<0.05).After treatment,the levels of inflammatory factors in both groups were significantly reduced than before treatment,and the study group was significantly lower than the control group (P<0.05).Conclusion Xuebijing combined with dopamine and phentolamine can effectively improve the gas and blood and coagulation function indexes,inhibit the body's inflammatory response,and Reduce mortality,which has worthy of application promotion in patients with acute exacerbation of COPD and multiple organ failure.