目的 研究谷氨酰胺聯(lián)合生長抑素對急性胰腺炎患者肝功能的影響。方法 選擇2015年1月-2017年12月安徽省第二人民醫(yī)院急診醫(yī)學科收治的50例急性胰腺炎患者，隨機分為對照組（n=25）和觀察組（n=25）。對照組將6 mg生長抑素加入至500 mL生理鹽水中進行靜脈滴注，每天1次。觀察組在對照組基礎(chǔ)上聯(lián)合靜脈滴注谷氨酰胺，每次20 g，每天1次。兩組均給藥7 d。記錄兩組的機械通氣時間、APACHE Ⅱ評分及住院時間，比較兩組肝功能和血清炎性細胞因子水平。結(jié)果 觀察組的有效率為92.00%，明顯高于對照組的76.00%，差異有統(tǒng)計學意義（P<0.05）。觀察組機械通氣時間、APACHE Ⅱ評分及住院時間均明顯低于對照組，差異有統(tǒng)計學意義（P<0.05）。治療后，兩組的天冬氨酸氨基轉(zhuǎn)移酶（AST）、總膽紅素（TBIL）和丙氨酸氨基轉(zhuǎn)移酶（ALT）均明顯降低，同組治療前后比較差異有統(tǒng)計學意義（P<0.05）；且觀察組以上指標明顯低于對照組，差異有統(tǒng)計學意義（P<0.05）。治療后，兩組的白介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）、白介素-8（IL-8）、超敏C反應蛋白（hs-CRP）均明顯降低，同組治療前后比較差異有統(tǒng)計學意義（P<0.05）；且觀察組以上指標明顯低于對照組，差異有統(tǒng)計學意義（P<0.05）。結(jié)論 谷氨酰胺聯(lián)合生長抑素可以有效改善急性胰腺炎患者的肝功能，抑制炎癥反應，效果明顯優(yōu)于單用生長抑素。

Objective To investigate the effect of somatostatin combined with glutamine on liver function in patients with acute pancreatitis.Methods Selected 50 cases of patients with acute pancreatitis who were treated in our hospital from January 2015 to December 2017,divided into the control group (n=25),and the observation group (n=25).The mechanical ventilation time,APACHE Ⅱ score and hospitalization time were recorded,and the liver function and serum inflammatory cytokine levels were compared before and after treatment.Results The effective rate of the observation group was 92.00%,which was significantly higher than that of the control group (76.00%,P<0.05).The duration of mechanical ventilation,APACHE Ⅱ score and hospitalization time in the observation group were significantly lower than those in the control group (P<0.05).After treatment,aspartate aminotransferase (AST),total bilirubin (TBIL) and alanine aminotransferase (ALT) in the two groups were significantly decreased,and there was significant difference before and after treatment in the same group (P<0.05);and the above indicators in the observation group were significantly lower than those in the control group (P<0.05).After treatment,the levels of interleukin-6(IL-6),tumor necrosis factor-alpha (TNF-alpha),interleukin-8(IL-8),and acute C-reactive protein (hs-CRP) in the two groups were significantly lower than those in the control group (P<0.05),and the above indexes in the observation group were significantly lower than those in the control group (P<0.05).Conclusion Somatostatin combined with glutamine can effectively improve liver function and inhibit inflammatory reaction in patients with acute pancreatitis,and the effect is better than somatostatin alone.