目的 系統(tǒng)評(píng)價(jià)地塞米松聯(lián)合地佐辛超前鎮(zhèn)痛用于外科術(shù)后鎮(zhèn)痛效果和安全性，為臨床應(yīng)用提供循證醫(yī)學(xué)證據(jù)。方法 計(jì)算機(jī)檢索PubMed、Embase、中國生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫（CBM）、中國知網(wǎng)（CNKI）、維普數(shù)據(jù)庫（VIP）和萬方數(shù)據(jù)庫，收集地塞米松聯(lián)合地佐辛（試驗(yàn)組）和單用地佐辛（對(duì)照組）超前鎮(zhèn)痛用于外科術(shù)后鎮(zhèn)痛的隨機(jī)對(duì)照研究，檢索時(shí)限為從建庫-2018年5月，提取有效數(shù)據(jù)后，應(yīng)用RevMan 5.2軟件進(jìn)行Meta-分析。結(jié)果 共納入13項(xiàng)研究，893例患者。Meta-分析結(jié)果顯示：試驗(yàn)組術(shù)后的VAS評(píng)分在2 h （MD=-0.63，95%CI=-0.86~-0.41，P<0.01）、4 h （MD=-0.31，95%CI=-0.41~-0.21，P<0.01）、8 h （MD=-0.85，95%CI=-1.08~-0.62，P<0.01）、12 h （MD=-0.89，95%CI=-1.05~-0.72，P<0.01）、24 h （MD=-1.16，95%CI=-1.49~-0.82，P<0.01）均小于對(duì)照組；鎮(zhèn)痛藥追加率（RR=0.08，95%CI=0.02~0.32，P<0.01）小于對(duì)照組；患者鎮(zhèn)靜滿意度（RR=1.18，95%CI=1.07~1.31，P<0.01）高于對(duì)照組；惡心、嘔吐發(fā)生率（RR=0.41，95%CI=0.30~0.56，P<0.01）低于對(duì)照組。結(jié)論 地塞米松聯(lián)合地佐辛具有良好的協(xié)同作用，可有效減輕術(shù)后疼痛，減少惡心嘔吐發(fā)生，值得臨床推廣。

Objective To evaluate the postoperative analgesia effect and safety of dexamethasone combined with dizocine in surgical patient,and provide evidence-based medical evidence for clinical applications.Methods The related databases of PubMed,Embase,CNKI,CBM,VIP,and Wanfang were electronically searched for clinical randomized controlled study about dexamethasone combined with dizocine (test group) vs dizocine alone (control group) in surgical patient from database establishment to May 2018,Meta-analysis using RevMan 5.2 software after extracting valid data.Result A total of 13 studies involving 893 patients were entered.Meta-analysis showed that,the test group in VAS score of 2 h after operation (MD=-0.63,95%CI=-0.86~-0.41,P<0.01),4 h after operation (MD=-0.31,95%CI=-0.41~-0.21,P<0.01),8 h after operation (MD=-0.85,95%CI=-1.08~-0.62,P<0.01),12 h after operation (MD=-0.89,95%CI=-1.05~-0.72,P<0.01) and 24 h after operation (MD=-1.16,95%CI=-1.49~-0.82,P<0.01) much lower than that in the control group;analgesic rate (RR=0.08,95%CI=0.02~0.32,P<0.01) of the test group much lower than that in the control group;patient sedation satisfaction (RR=1.18,95%CI=1.07~1.31,P<0.01) of the test group much higher than that in the control group;Incidence of nausea and vomiting (RR=0.41,95%CI=0.30~0.56,P<0.01) of the test group much lower than that in the control group.Conclusion Dexamethasone combined with dextrozine has a good synergistic and additive effect,which can effectively reduce postoperative pain and reduce the incidence of nausea and vomiting,which is worthy of clinical promotion.