高三尖杉酯堿存在于三尖杉屬植物，2012年被美國(guó)FDA批準(zhǔn)上市用于慢性粒細(xì)胞白血病，引起醫(yī)藥工作者更廣泛關(guān)注。目前，在其原料藥的來(lái)源途徑、理化性質(zhì)、抗癌活性、臨床應(yīng)用、作用機(jī)制等方面已積累了較大量文獻(xiàn)，現(xiàn)有綜述主要集中在抗癌機(jī)制及在血液病應(yīng)用方面，對(duì)藥物研發(fā)有重要影響的原料藥來(lái)源、理化性質(zhì)、質(zhì)量控制、構(gòu)效關(guān)系等少有梳理。本文以"homoharringtonine"、"Cephalotaxine"、"Tissue culture"、"SAR"等為中、英文主題詞，查詢Elsevier及cnki、vip、Wanfang等數(shù)據(jù)庫(kù)，歸納整理上述內(nèi)容，以期為深入開發(fā)奠定基礎(chǔ)。

Homoharringtonine exists in the genus Cephalotaxine,approved by FDA for chronic myeloid leukemia in 2012,causing wider concern for pharmaceutical workers.At present,a large number of literatures have been accumulated on the origin of its raw material drugs,physicochemical properties,anticancer activity,clinical application,mechanism of action and so forther.The current review focuses on anticancer mechanisms and applications in hematologic diseases,The origin of raw material drugs,physical and chemical properties,quality control and structure-activity relationship which have important influence on drug research and development are rarely combed.This artical takes "homoharringtonine","Cephalotaxine" "Tissue culture","SAR"as the Chinese and English subject words,queries databases including Elsevier and CNKI,vip,Wanfangand so forther,summarize the above contents,in order to lay the foundation for further development.

黑龍江省自然科學(xué)基金（H2016057，H2017066）；黑龍江中醫(yī)藥大學(xué)"優(yōu)秀創(chuàng)新人才支持計(jì)劃"項(xiàng)目（2012）；國(guó)家教育部春暉計(jì)劃（Z2008-1-15016）；黑龍江省教育廳骨干教師基金（1251 G058）