槐定堿和氧化槐定堿是中藥苦豆子中的主要活性成分，可能通過抗氧化、抗炎、抗細(xì)胞凋亡、調(diào)節(jié)鈣循環(huán)等途徑，表現(xiàn)出對(duì)心力衰竭、心肌梗死、腦缺血、腦缺血再灌注損傷等心腦血管疾病的良好防治效果。綜述近年來槐定堿和氧化槐定堿對(duì)心腦血管疾病的防治作用及其作用機(jī)制的研究進(jìn)展，為臨床應(yīng)用槐定堿和氧化槐定堿治療心腦血管疾病提供參考。

Sophoridine and oxysophoridine are the essential components of traditional Chinese medicine Sophora alopecuroides L.Pharmacological research results showed that sophoridine and oxysophoridine were effective in preventing and treating cardiovascular and cerebrovascular diseases such as heart failure,myocardial infarction,cerebral ischemia and cerebral ischemia reperfusion injury through anti-oxidation,anti-inflammation,anti-apoptosis and regulating calcium circulation.This paper reviewed the effects and mechanisms of sophoridine and oxysophoridine on cardiovascular and cerebrovascular diseases,which can provide references for treatment of cardiovascular and cerebrovascular diseases with sophoridine and oxysophoridine.

河南省科技廳科技攻關(guān)項(xiàng)目（172102310208）；河南省教育廳自然科學(xué)計(jì)劃項(xiàng)目（16A180046）