目的 研究三七Panax notoginseng莖葉皂苷水解轉化產(chǎn)物的化學成分，以期發(fā)現(xiàn)新的苷元。方法 三七莖葉皂苷酸水解產(chǎn)物通過硅膠、凝膠及液相色譜進行分離，分離得到的化合物結構經(jīng)譜學方法鑒定。結果 從三七莖葉皂苷水解產(chǎn)物中分離得到7個單體化合物，分別鑒定為20(S)-3-甲氧基-人參二醇（1）、20(E)-達瑪烷-20 (22)-烯-3β, 12β, 25-三醇（2）、20(R)-達瑪烷-3β, 6α, 12β, 20, 25-五醇（3）、20(R)-達瑪烷-3β, 12β, 20, 25-四醇（4）、擬人參皂苷-F₁₁苷元（5）、20(S)-人參二醇（6）、20(S)-原人參二醇（7）。結論 化合物1為一新化合物，命名為三七皂苷元MPD。

Abstract: Objective To study the chemical constituents of the hydrolyzed products and to find the rare aglycones from the stems and leaves of Panax notoginseng. Methods The acid hydrolysate was separated by repeated silica gel, Sephadex LH-20, and HPLC chromatographies, and their structures were identified by the analysis of spectral data. Results Seven monomer compounds were isolated from the hydrolyzed products and identified as 20(S)-3-methoxyl-panaxadiol (1), 20(E)-dammarane-20(22)en-3β, 12β, 25- panaxatriol (2), 20(R)-dammarane-3β, 6α, 12β, 20, 25-pentol (3), 20(R)-dammarane-3β, 12β, 20, 25-triol (4), 24(R)-ocotillol (5), 20(S)-panaxadiol (6), and 20(S)-protopanaxadiol (7). Conclusion Compound 1 is a new compound, named notoginsengaglycone MPD.

國家科技重大專項項目（2009ZX09102-114；2010ZX09401-304-105B）；遼寧省博士啟動項目（20101108）