目的 比較川木香煨制前后主要藥效成分木香烴內(nèi)酯和去氫木香內(nèi)酯在大鼠胃、小腸、結(jié)腸的吸收差異。方法 建立大鼠原位胃、小腸、結(jié)腸吸收灌注模型，HPLC-UV法測(cè)定給藥后各灌注液中木香烴內(nèi)酯、去氫木香內(nèi)酯和酚紅的量，獲取川木香煨制前后主要藥效成分在胃、小腸、結(jié)腸中吸收動(dòng)力學(xué)參數(shù)。結(jié)果 川木香生品中木香烴內(nèi)酯和去氫木香內(nèi)酯在大鼠胃和小腸中的每小時(shí)吸收百分率較煨制品高（P＜0.05），川木香煨制品中木香烴內(nèi)酯和去氫木香內(nèi)酯在結(jié)腸中的每小時(shí)吸收百分率較生品高（P＜0.01）。結(jié)論 川木香煨制品中藥效成分在結(jié)腸中吸收速度高于生品。

Objective To analyze the absorption difference of the principal active components in Vladimiriae Radix, costunolide and dehydrocostuslactone, between the crude Vladimiriae Radix (CVR) and roasting-processed Vladimiriae Radix (RPVR), in stomach, small intestine, and colon in rats. Methods The in situ perfusion models of stomach, small intestine, and colon in rats were established, the contents of costunolide, dehydrocostuslactone, and phenol red were determined using HPLC-UV method, and the parameters of absorption kinetics of the test object in stomach, small intestine, and colon were obtained. Results The absorption percentage per hour of costunolide and dehydrocostuslactone in CVR was higher than that in RPVR in stomach and small intestine of rats (P < 0.05). However, the absorption percentage per hour of costunolide and dehydrocos in RPVR was higher than that in CVR in colon of rats (P < 0.01). Conclusion The absorption rate of cstunolide and dehydrocostuslactone in CVR is higher than that in PVR sample in colon of rats.

國(guó)家自然科學(xué)基金青年基金資助項(xiàng)目（81001638）