目的 研究云南沉香Aquilaria yunnanensis果殼的化學(xué)成分。方法 采用硅膠、Sephadex LH-20柱色譜和半制備HPLC技術(shù)進(jìn)行分離、純化，結(jié)合理化性質(zhì)和波譜數(shù)據(jù)鑒定化合物的結(jié)構(gòu)。結(jié)果 從云南沉香果殼的95%乙醇提取物的醋酸乙酯萃取部位中分離得到13個(gè)化合物，分別鑒定為trans-linalool-3，6-oxide-7-O-β-D-（6'-O-acetyl）-glucoside（1）、苯乙基-8-O-β-D-（6'-O-乙?；?葡萄糖苷（2）、芒果苷（3）、鳶尾酚酮-3，5-C-β-D-二葡萄糖苷（4）、山柰酚-3-O-β-D-葡萄糖苷（5）、木犀草素-7-O-β-D-葡萄糖苷（6）、異鼠李素-3-O-β-D-葡萄糖苷（7）、山柰酚-3-O-β-D-（6''-對(duì)-香豆?；?葡萄糖苷（8）、香葉醇-1-O-β-D-葡萄糖苷（9）、3-[2-甲酰基-5-（羥甲基）-1H-吡咯-1-基]戊二酸（10）、大麻酰胺D（11）、淫羊藿次苷D₂（12）、松柏苷（13）。結(jié)論 化合物1為新的單萜苷類化合物，命名為云南沉香苷C，化合物2為新天然產(chǎn)物，7、9～13為首次從沉香屬植物中分離得到，所有化合物均為首次從該植物中分離得到。

Objective To investigate the chemical constituents from the pericarps of Aquilaria yunnanensis. Methods The chemical constituents were separated and purified by silica gel, Sephadex LH-20 column chromatography, and semi-preparative HPLC. The structures of isolated compounds were identified by physicochemical properties and spectroscopic data. Results Thirteen compounds were isolated from the ethyl acetate layer of 95% EtOH extract of the pericarps of A. yunnanensis, and identified as trans-linalool-3,6-oxide-7-O-β-D-(6'-O-acetyl)-glucoside (1), phenethyl-8-O-β-D-(6'-O-acetyl)-glucoside (2), mangiferin (3), iriflophenone-3,5-C-β-D-diglucoside (4), kaempferol-3-O-β-D-glucoside (5), luteolin-7-O-β-D-glucoside (6), isorhamnetin-3-O-β-D-glucoside (7), kaempferol-3-O-β-D-(6''-p-coumaroyl)-β-D-glucoside (8), geraniol-1-O-β-D-glucoside (9), 3-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl] pentanedioic acid (10), cannabisin D (11), icariside D₂ (12), and coniferin (13). Conclusion Compound 1 is a new compound and compound 2 is a new natural product. Compounds 7, 9-13 were obtained from the Aquilaria genus for the first time. All compounds were firstly isolated from A. yunnanensis.

國家重點(diǎn)研發(fā)計(jì)劃“中醫(yī)藥現(xiàn)代化研究”重點(diǎn)專項(xiàng)資助項(xiàng)目（2018YFC1706402）；國家中藥標(biāo)準(zhǔn)化項(xiàng)目（ZYBZH-Y-GD-13-ZYY-2017-076）；創(chuàng)新天然藥物與中藥注射劑國家重點(diǎn)實(shí)驗(yàn)室開放課題（QFSKL2018001）