目的 研究三尖杉Cephalotaxus fortunei的化學(xué)成分。方法 采用薄層色譜、正相硅膠柱色譜、ODS反相柱色譜、HP20大孔樹脂及Sephadex LH-20凝膠柱色譜、高效液相制備色譜等分離技術(shù)進行分離，運用¹H-NMR、¹³C-NMR、ESI-MS等多種波譜技術(shù)鑒定化合物的結(jié)構(gòu)。結(jié)果 從三尖杉的乙醇提取物中分離得到了17個木脂素類化合物，分別鑒定為shonanin（1）、牛蒡子苷元（2）、α-鐵杉脂素（3）、羅漢松脂酚（4）、去甲絡(luò)石苷元（5）、表去甲絡(luò)石苷元（6）、（7'S）-羥羅漢脂素（7）、（7'R）-羥羅漢脂素（8）、（7'S）-hydroxyarctigenin（9）、開環(huán)異落葉松樹脂酚（10）、4，4'-di-O-methylcephafortinA（11）、5-（3''，4''-二甲氧基苯基）-3-羥基-3-（4'-羥基-3'-甲氧基芐基）-4-羥甲基二氫呋喃-2-酮（12）、cephafortin B（13）、二氫去氫二愈創(chuàng)木基醇（14）、7R，8S-4，7，9，9'-四羥基-3，3'-二甲氧基-8-O-4'-新木脂素（15）、7R，8R-4，7，9，9'-四羥基-3，3'-二甲氧基-8-O-4'-新木脂素（16）、threo-1，2-雙（4-羥基-3-甲氧基苯基）-1，3-丙二醇（17）。結(jié)論 化合物3、6、10、17為首次從三尖杉屬植物中分離得到，4、5、7～9、12、14為首次從三尖杉中分離得到。

Objective To study chemical constituents of Cephalotaxus fortunei. Methods The chemical constituents were separated and purified by preparative thin-layer chromatography, silica gel, ODS, HP20 macroporous resin and Sephadex LH-20 gel column chromatography, and semi-preparative HPLC. Their structures were determined by NMR and ESI-MS spectroscopic techniques. Results Seventeen lignans were isolated from the ethanol extracts of C. fortunei and their structures were identified as shonanin (1), arctigenin (2), α-conidendrin (3), matairesinol (4), nortrachelogenin (5), epinortrachelogenin (6), (7'S)-hydroxymatairesinol (7), (7'R)-hydroxymatairesanol (8), (7'S)-hydroxyarctigenin (9), secoisolariciresinol (10), 4,4'-di-O-methylcephafortin A (11), 5-(3'',4''-dimethoxyphenyl)-3-hydroxy-3-(4'-hydroxy-3'-methoxybenzyl)-4-hydroxymethyl-dihydrofuran-2-one (12), cephafortin B (13), dihydrodehydrodiconiferyl alcohol (14), 7R,8S-4,7,9,9'-tetrahydroxy-3,3'-dimethoxy-8-O-4'-neolignan (15), 7R,8R-4,7,9,9'-tetrahydroxy-3,3'-dimethoxy-8-O-4'-neolignan (16), and threo-1,2-bis-(4-hydroxy-3-methoxyphenyl)-1,3-propanediol (17). Conclusion Compounds 3, 6, 10 and 17 were isolated from genus Cephalotaxus for the first time, and compounds 4, 5, 7-9, 12 and 14 were isolated from C. fortunei for the first time.