中藥指紋圖譜的建立以及譜效關(guān)系的研究是目前檢控中藥質(zhì)量的重要趨勢，其以化學成分系統(tǒng)研究為基礎(chǔ)，可用于評價生藥、飲片、中成藥的真實性、優(yōu)劣性及穩(wěn)定性，但受到諸多不穩(wěn)定因素的影響以及缺乏與傳統(tǒng)中醫(yī)藥理論的關(guān)聯(lián)性。而中藥質(zhì)量標志物（Q-marker）的提出，為指紋圖譜及譜效關(guān)系的研究提供了新的思路和方法。以金銀花為例，探究基于中藥Q-marker理論指導下，中藥指紋圖譜評價體系的研究思路與方法的建立。

The establishment of fingerprint system and the study of spectrum-effect relationship have become a very important development trend in quality evaluation of Chinese materia medica (CMM). It is based on the research of index components and can be used to evaluate the authenticity, quality and stability of crude drug, pieces and patent medicines of CMM. However, it is affected by many unstable factors and lacks of relevance to traditional Chinese medicine theories. Quality marker, in due course, provides an enlightening thought and way for the fingerprint system and spectrum-effect relationship studies. Taking Lonicerae Japonicae Flos as an example, this paper explores the researching ideas and establishes methods for fingerprinting research on CMM based on the characteristics of Q-markers.

國家自然科學基金項目（81603232）；河南中醫(yī)藥大學博士科研基金項目（BSJJ2015-13）；鄭州市科技攻關(guān)計劃項目（0910SGYS33391-6）