狼毒Euphorbiae Ebracteolatae Radix為大戟科（Euphorbiaceae）植物狼毒大戟Euphorbia fischeriana或月腺大戟E.ebracteolata的干燥根，是一種廣泛應用，具有廣闊開發(fā)前景的中藥材。狼毒含有多種生物活性成分，其中二萜類化合物是最為重要的一個部分，主要包括松香烷型、巴豆烷型、海松烷型、玫瑰烷型、西松烷型、巨大戟烷型、貝殼杉烷型、阿替斯烷型8種類型，此外還有少量二萜二聚體及其他類型的二萜類化合物。狼毒二萜類化學成分具有顯著的抗腫瘤、抗炎、抗菌、抗病毒等藥理作用。對狼毒二萜類化學成分及其藥理作用進行綜述，以期為更好地開發(fā)狼毒資源及其臨床應用提供參考。

Euphorbiae Ebracteolatae Radix is the dry root of plant Euphorbia fischeriana or E. ebracteolata of Euphorbiaceae, which is a widely utilized natural medicine with broad development prospect. It has been discovered that Euphorbiae Ebracteolatae Radix contains several biologically active constituents, among which diterpenoids are the most important. The diterpenoids of Euphorbiae Ebracteolatae Radix contain eight types including abietane-type, tigliane-type, pimarane-type, rosane-type, cembrane-type, ent-kaurane-type, ingenane-type and atisane-type. Diterpenoids of Euphorbiae Ebracteolatae Radix have significant anti-tumor, anti-inflammatory, anti-viral and other pharmacological activities. In this paper, the chemical constituents of diterpenoids and pharmacological activities of Euphorbiae Ebracteolatae Radix in recent years were reviewed in order to provide references for better developing the resources of Euphorbiae Ebracteolatae Radix and its clinical application.

國家自然科學基金青年科學基金項目（81903789）