類風(fēng)濕關(guān)節(jié)炎（RA）是一種以滑膜持續(xù)炎癥和關(guān)節(jié)軟骨及骨質(zhì)破壞為特征的慢性自身免疫性疾病，隨著人口老齡化不斷加劇，RA的發(fā)病率逐年升高，公共衛(wèi)生負(fù)擔(dān)日趨嚴(yán)重。雷公藤具有祛風(fēng)通絡(luò)、除濕止痛、解毒殺蟲的功效，臨床常用于治療多種自身免疫性疾病、腫瘤及皮膚病等，尤其在治療RA方面療效顯著。從實驗藥理學(xué)與臨床研究2個方面系統(tǒng)綜述近年來雷公藤治療RA的最新研究進展，包括雷公藤單味藥應(yīng)用、雷公藤與其他中藥配伍應(yīng)用以及雷公藤與化學(xué)藥聯(lián)合用藥，以期促進雷公藤用于RA治療的創(chuàng)新藥物研發(fā)與臨床合理有效應(yīng)用。

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovitis and destruction of articular cartilage and bone. With the aging of the population, the incidence of RA is increasing year by year and the burden of public health is becoming more and more serious. Tripterygium wilfordii has the effects of dispelling wind and dredging collaterals, dehumidifying and relieving pain, detoxification and insecticide. It is often used in the treatment of various autoimmune diseases, tumors and skin diseases in clinic, and the prominent effect is observed in the treatment of RA especially. This review systematically summarizes and discusses the latest research progress of T. wilfordii in the treatment of RA in the aspects of experimental pharmacology and clinical research, including its single application, the compatible application with other Chinese materia medica, and the combination of Western medicine, which is expected to promote the innovative drug development and more reasonable and effective clinical application of T. wilfordii in the treatment of RA.

國家重點研發(fā)計劃課題（2019YFC1711003）；陜西中醫(yī)藥大學(xué)校級科研課題研究生創(chuàng)新項目（2020年度）；陜西中醫(yī)藥大學(xué)學(xué)科創(chuàng)新團隊項目（2019-YL10）