目的 制備局部給藥的金銀花提取物超分子水凝膠，并對(duì)其進(jìn)行表征和體外釋放行為研究。方法 采用40%乙醇提取金銀花，以酚酸類成分的含量為定量指標(biāo)，選取N-芴甲氧羰基-L-苯丙氨酸為凝膠因子，制備金銀花提取物超分子水凝膠，采用體外釋放實(shí)驗(yàn)研究其釋放行為。結(jié)果 加入金銀花提取物，不影響超分子水凝膠的形成及其抗菌性能，還有利于提高超分子水凝膠的穩(wěn)定性。金銀花提取物的釋放行為與其負(fù)載量和釋放介質(zhì)pH值有關(guān)，金銀花提取物的負(fù)載量為0.5 mg/mL時(shí)，其累積釋放率最大；提取液的累積釋放率隨釋放介質(zhì)的pH值升高而增大，表現(xiàn)出明顯的緩控釋特征。結(jié)論 超分子水凝膠作為金銀花提取物的釋放載體，具有明顯的緩控釋作用，為金銀花在醫(yī)藥方面的開發(fā)和應(yīng)用提供了新思路。

Objective To prepare the Lonicerae Japonicae Flos (LJF) extract supramolecular hydrogel and investigate its properties and release behavior in vitro. Methods The LJF was extracted with 40% ethanol. Taking the content of phenolic acids as the quantitative index, N-(9-fluorenylmethoxycarbonyl)-L-phenylalanine was selected as the gelator to prepare LJF extract supramolecular hydrogels. The release behavior was studied by in vitro release experiment. Results The addition of LJF extract not only did not affect the formation of supramolecular hydrogel, but also improved the stability of supramolecular hydrogel. The release behavior of LJF extract was related to its loading and pH value of release medium. When the drug loading of LJF extract was 0.5 mg/mL, the cumulative release rate was the highest. Moreover, the cumulative release rate increased with the pH value of the release medium, showing obvious controlled release characteristics. Conclusion Supramolecular hydrogels as the release carrier for LJF extract have an obvious sustained and controlled release, which provides a new idea for the development and application of LJF in medicine.

R283.6

國(guó)家自然科學(xué)基金項(xiàng)目（81803735）；湖北省自然科學(xué)基金項(xiàng)目（2018CFB354）；湖北省教育廳指導(dǎo)性項(xiàng)目（B2018101）