隨著現(xiàn)代慢性復(fù)雜性疾病發(fā)病率的攀升以及中醫(yī)藥在治療慢性病方面的優(yōu)勢(shì)日益凸顯，中藥的國(guó)內(nèi)外地位與日俱增。而中藥活性成分、效應(yīng)物質(zhì)及相應(yīng)作用機(jī)制的未知性極大限制了中藥的臨床接受度與國(guó)際化進(jìn)程。發(fā)現(xiàn)直接關(guān)切中藥藥效的活性成分及效應(yīng)物質(zhì)是中藥研究的關(guān)鍵科學(xué)問題之一。在回顧目前中藥活性成分發(fā)現(xiàn)模式的基礎(chǔ)上，跟蹤國(guó)際研究前沿，結(jié)合中藥成分特征，依據(jù)大多數(shù)中藥通過口服給藥的特點(diǎn)，結(jié)合課題組相關(guān)研究基礎(chǔ)，探討基于腸道微生態(tài)的中藥活性成分與效應(yīng)物質(zhì)發(fā)現(xiàn)研究模式，以期為中藥新藥研發(fā)及作用機(jī)制研究等方面提供新思路，助力中藥現(xiàn)代化與國(guó)際化。

With the increase of the chronic complex diseases and the growing advantage of traditional Chinese medicine (TCM) in treating chronic complex diseases, Chinese materia media (CMM) became more and more importance in the world. However, the ambiguity of bioactive compounds, effective materials and their corresponding mechanisms has limited the acceptance of CMM in clinic and the internalization of CMM in the world. As a result, the discovery of bioactive compounds and effective materials that are directly associated with therapeutic effects of CMM is one of the most important scientific question in researching of CMM. Hence, in this article, we briefly reviewed current methods for discovery of bioactive compounds and effective materials. Then, with references related to the international research frontier and the characteristics of CMM ingredients, according to the characteristics of most Chinese medicine through oral administration, combined with the previous research basis of our research group, a research model that is based on gut microbiota was investigated to discover bioactive compounds and effective materials. The aim of this research model is to provide new thoughts on discovery of new drugs, the mechanism study of CMM, etc., and eventually promote the modernization and internalization of CMM.

R284;R285

國(guó)家自然科學(xué)基金項(xiàng)目（81891012）；國(guó)家自然科學(xué)基金項(xiàng)目（81630101）；國(guó)家自然科學(xué)基金項(xiàng)目（81503272）；國(guó)家自然科學(xué)基金項(xiàng)目U19A2010）；國(guó)家科技重大專項(xiàng)重大新藥創(chuàng)制（2108ZX09721001-008）；四川省科技廳青年科技創(chuàng)新研究團(tuán)隊(duì)（2017TD0001）