蒽醌及其衍生物是植物體內(nèi)十分重要的次級(jí)代謝產(chǎn)物，具有光保護(hù)、提高植物抗病性等多種功能，同時(shí)在醫(yī)藥、化工等領(lǐng)域也具有十分重要的應(yīng)用。如何高效、快速地獲得蒽醌類物質(zhì)、提高植物體內(nèi)蒽醌類物質(zhì)的合成效率，已經(jīng)成為現(xiàn)代合成生物學(xué)的研究熱點(diǎn)。然而蒽醌類物質(zhì)合成途徑較為復(fù)雜，目前普遍認(rèn)為在植物體內(nèi)蒽醌類物質(zhì)是通過莽草酸/鄰琥珀酰苯甲酸途徑和聚酮途徑形成。綜述近年來在植物體內(nèi)莽草酸/鄰琥珀酰苯甲酸途徑和聚酮途徑合成蒽醌母核結(jié)構(gòu)的研究進(jìn)展，為研究植物體內(nèi)蒽醌類代謝物的合成與調(diào)控提供一定的理論基礎(chǔ)。

Anthraquinone and its derivatives are very important secondary metabolites in plants. They have many functions such as photoprotection and improvement of plant disease resistance. They also have very important applications in the fields of medicine and chemical engineering. Efficiently and quickly obtaining anthraquinones and improving the synthesis efficiency of anthraquinones in plants have become one of the research focuses of modern synthetic biology. However, the synthetic pathway of anthraquinones is more complicated. At present, it is generally believed that anthraquinones are formed in plants by the shikimic acid/o-succinylbenzoic acid pathway and polyketone pathway. This article focuses on the recent research advances in the skeleton synthesis of anthraquinone via shikimic acid/o-succinylbenzoic acid pathway and polyketone pathway in plants, and provides a certain theoretical basis for studying the synthesis and regulation of anthraquinone metabolites in plants.

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國(guó)家重點(diǎn)研發(fā)課題（2017YFD0201402）；國(guó)家中醫(yī)藥管理局中藥標(biāo)準(zhǔn)化研究項(xiàng)目（ZYBZH-Y-GS-11）；國(guó)家自然科學(xué)基金資助項(xiàng)目（81803653）；天津市科技計(jì)劃項(xiàng)目（19YFZCSY00170）；天津市北辰區(qū)科技創(chuàng)新專項(xiàng)（KJCX-CXY-2019-13）；大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練計(jì)劃（201910069007，201910069102）；甘肅省現(xiàn)代農(nóng)業(yè)中藥材產(chǎn)業(yè)體系首席專家（GARS-ZYC-1）；甘肅省科技創(chuàng)新劵（V20198TA0459）