膝骨關節(jié)炎（knee osteoarthritis，KOA）是一種受多種因素影響最終導致軟骨細胞凋亡、細胞外基質(zhì)降解和軟骨下骨異常丟失的慢性關節(jié)疾病。中醫(yī)藥治療KOA有著悠久的歷史和廣闊的應用前景，能夠有效彌補現(xiàn)代醫(yī)學治療KOA的不足。地黃Rehmannia glutinosa及其有效成分梓醇、桃葉珊瑚苷、紅景天苷、松果菊苷、毛蕊花糖苷等具有一定干預KOA的作用。通過對地黃提取物及其單體成分治療KOA的作用機制，包括抑制促炎細胞因子的分泌、減慢軟骨基質(zhì)的降解、促進軟骨細胞增殖、抑制軟骨細胞凋亡、調(diào)節(jié)軟骨細胞自噬、抗氧化應激損傷、調(diào)節(jié)成骨細胞和破骨細胞平衡與細胞分化以保護軟骨下骨、緩解滑膜組織炎癥等方面的研究進展進行綜述，為進一步研究地黃及其有效成分防治KOA提供理論依據(jù)。

Knee osteoarthritis (KOA) is a chronic joint disease that results in chondrocyte apoptosis, extracellular matrix degradation and abnormal loss of subchondral bone due to multiple factors. The treatment of KOA by traditional Chinese medicine has a long history and broad application prospect, which can effectively make up for the deficiency of modern medicine. Dihuang (Rehmannia glutinosa) and its active components catalpol, aucubin, salidroside, echinacoside and acteoside can interfere with KOA. By studying the mechanism of action of R. glutinosa extract and its monomer components in treating KOA, the research progress in inhibiting the secretion of pro-inflammatory cytokines, slowing down the degradation of cartilage matrix, promoting chondrocyte proliferation, inhibiting chondrocyte apoptosis, regulating chondrocyte autophagy, resisting oxidative stress injury, regulating the balance and cell differentiation of osteoblasts and osteoclasts to protect subchondral bone and relieve synovial tissue inflammation was reviewed. It provides theoretical basis for further research on R. glutinosa and its effective components to control KOA.

R285

2023年遼寧省科學技術廳項目(2023-MSLH-150);2023年沈陽市科技人才專項項目(RC230094)