糖尿病腎病（diabetic nephropathy，DN）是糖尿病最常見的并發(fā)癥之一，發(fā)病機制復雜，隨著腎臟中腎小球、腎小管和腎間質(zhì)等不斷被破壞，最終可發(fā)展為慢性腎臟病（chronic kidney disease，CKD）和終末期腎?。╡nd-stage renal disease，ESRD），需要進行長期的持續(xù)治療。山茱萸Corni Fructus首載于《神農(nóng)本草經(jīng)》，具有補益肝腎、收澀固脫的功效，是保護腎臟的代表性藥物。研究表明，山茱萸能夠通過抑制炎癥、減少氧化應激、調(diào)節(jié)自噬及腸道菌群等方式降低血糖、減少足細胞凋亡、緩解腎臟病理損傷、改善腎臟纖維化狀況。對DN的病因病機進行了闡釋，總結(jié)了山茱萸中的部分有效成分如山茱萸新苷、莫諾苷、馬錢苷，山茱萸提取物，炮制山茱萸以及山茱萸藥對和復方在治療DN方面的作用機制及研究進展，為臨床應用山茱萸治療DN提供依據(jù)，為山茱萸的進一步研究與開發(fā)應用提供參考。

Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus with complex pathogenesis. With the continuous destruction of glomeruli, tubules and interstitium in the kidney, it can eventually develop into chronic kidney disease (CKD) and end-stage renal disease (ESRD), which requires long-term continuous treatment. Shanzhuyu (Corni Fructus), first published in the Shen Nong’s Herbal Classic, has the efficacy of tonifying the liver and kidneys, relieving collapse with astringent therapy, and is a representative medicine for protecting the kidneys. Studies have shown that Corni Fructus is able to lower blood glucose, reduce podocyte apoptosis, alleviate renal pathological damage and improve renal fibrosis by inhibiting inflammation, reducing oxidative stress, and regulating autophagy and gut flora. This paper elucidates the etiology and pathogenesis of DN, summarizes the mechanism of action and research progress of some of the active components in Corni Fructus, such as cornuside, morroniside and loganin, Corni Fructus extracts, processing Corni Fructus, as well as Corni Fructus medicinal pairs and combinations in the treatment of DN. It provides a basis for the clinical application of Corni Fructus in the treatment of diabetic nephropathy and a reference for further research and development of Corni Fructus applications.

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黑龍江省醫(yī)藥衛(wèi)生科研課題（20230202080141）