糖尿病是以血糖水平慢性增高為特征的代謝性疾病，其患病率高、并發(fā)癥多、疾病負擔重。蛋白質(zhì)翻譯后修飾（post-translational modifications，PTMs）是蛋白質(zhì)組結(jié)構(gòu)和功能具有復雜性和變異性的核心之一，PTMs通過將特定化學基團等與氨基酸連接來動態(tài)調(diào)節(jié)蛋白質(zhì)結(jié)構(gòu)、活性、定位和分子互作進而影響細胞活動。大量研究表明，PTMs參與糖尿病及其并發(fā)癥的發(fā)生和發(fā)展，調(diào)控PTMs并尋找相應(yīng)的藥物靶點有望成為干預糖尿病等代謝性疾病的新選擇。近年來，臨床前研究揭示了中藥調(diào)節(jié)PTMs進而防治糖尿病及其并發(fā)癥的應(yīng)用潛力，但缺乏系統(tǒng)梳理與總結(jié)展望。通過對中醫(yī)藥調(diào)控PTMs防治糖尿病及其并發(fā)癥的研究進行綜述，為糖尿病及其并發(fā)癥的治療提供新的見解，為相關(guān)新藥的研發(fā)提供新的思路。

Diabetes is a metabolic disease characterized by chronically elevated blood sugar levels, which has a high prevalence, multiple complications, and a heavy disease burden. Post-translational modifications (PTMs) are one of the cores for the complexity and variability of proteomics structure and function, dynamically regulating the protein structure, activity, location, and molecular interactions to impact cell functions by attaching specific chemical groups to amino acids. Increasing research indicates that PTMs are involved in the occurrence and development of diabetes and its complications. Modulating PTMs and identifying corresponding drug targets may become a new option for intervening in metabolic diseases like diabetes. In recent years, preclinical studies have revealed the potential applications of traditional Chinese medicine (TCM) and its active ingredients in targeting PTMs to intervene in diabetes and its complications. Therefore, this article will review the intervention of diabetes and its complications by modulating PTMs with TCM and its active ingredients in the hope of providing new insights for treatment of diabetes and its complications, and offering new perspectives for the development of related new drugs.

R285

中央高水平醫(yī)院臨床科研業(yè)務(wù)費資助（北京大學第一醫(yī)院青年臨床研究專項）（2023YC32）;國家中西醫(yī)協(xié)同慢病管理研究項目（CXZH2024154）;中醫(yī)藥傳承與創(chuàng)新“百千萬”人才工程（岐黃工程）—國家中醫(yī)藥領(lǐng)軍人才支持計劃[國中醫(yī)人教函（2022）6號];山西省中醫(yī)藥管理局科研課題（2024ZYY2C132）;北京大學第一醫(yī)院培育基金（2024PY07）