糖尿病腎病（diabetic nephropathy，DN）是糖尿病患者常見的微血管并發(fā)癥之一，已成為導(dǎo)致終末期腎病的主要原因。該病起病隱匿，在臨床治療中往往錯(cuò)過最佳干預(yù)時(shí)機(jī)，嚴(yán)重影響患者的生活質(zhì)量和生命安全。姜黃素是一種從姜黃根莖中提取的多酚類化合物，具有廣泛的藥理作用。近年來，隨著對(duì)姜黃素研究的不斷深入，其在DN治療中的應(yīng)用受到廣泛關(guān)注。通過分析姜黃素治療DN的臨床前研究和臨床研究，發(fā)現(xiàn)其能夠通過改善糖脂代謝紊亂、抑制炎癥反應(yīng)和氧化應(yīng)激、減輕腎纖維化與細(xì)胞凋亡、調(diào)節(jié)腸道菌群失衡及維持自噬平衡等多種機(jī)制，對(duì)DN發(fā)揮保護(hù)作用。為姜黃素治療DN的基礎(chǔ)研究、藥物開發(fā)與臨床應(yīng)用提供重要參考。

Diabetic nephropathy (DN) is one of the common microvascular complications in patients with diabetes mellitus, and has become a major cause of end-stage renal disease. The disease has an insidious onset and often misses the best time for intervention in clinical treatment, which seriously affects the quality of life and life safety of patients. Curcumin is a polyphenolic compound extracted from the rhizome of Jianghuang (Curcumae Longae Rhizoma), which has a wide range of pharmacological effects. In recent years, with the continuous deepening of the research on curcumin, its application in treatment of DN has received widespread attention. By analyzing the preclinical and clinical studies of curcumin in treatment of DN, it was found that it can exert a protective effect on DN through a variety of mechanisms, such as improving the disorders of glucose and lipid metabolism, inhibiting inflammatory response and oxidative stress, attenuating renal fibrosis and apoptosis, regulating the imbalance of intestinal flora, and maintaining the balance of autophagy. To provide an important reference for the basic research, drug development and clinical application of curcumin in treatment of DN.

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國家自然科學(xué)基金資助項(xiàng)目（82405343）;河南省中醫(yī)藥拔尖人才培養(yǎng)項(xiàng)目（2022ZYBJ08）;河南省科技攻關(guān)項(xiàng)目（232102310458）;河南省中醫(yī)藥科學(xué)研究專項(xiàng)（2019JDZX2116）;河南省高等學(xué)校重點(diǎn)科研項(xiàng)目（25A360004）