[關(guān)鍵詞]
[摘要]
中藥方劑配伍理論是指導(dǎo)中藥成方和臨床合理用藥的基本理論，體現(xiàn)了中藥的藥性理論和用藥法度，是中藥的特色與優(yōu)勢(shì)。合理的方劑配伍能影響其所含化學(xué)成分的吸收、分布、代謝和排泄的體內(nèi)藥物代謝動(dòng)力學(xué)行為，能夠在增強(qiáng)療效的同時(shí)消除或減弱藥物的不良反應(yīng)。轉(zhuǎn)運(yùn)體和代謝酶是藥物完成生物轉(zhuǎn)化的重要組成部分，中藥配伍引起轉(zhuǎn)運(yùn)體和代謝酶功能改變是方劑中藥效成分體內(nèi)過程發(fā)生變化的重要機(jī)制。研究基于轉(zhuǎn)運(yùn)體及代謝酶的中藥相互作用是闡明方劑配伍規(guī)律的重要方向之一，有助于闡明中藥方劑配伍規(guī)律和中藥毒性的科學(xué)內(nèi)涵，為臨床組方用藥提供科學(xué)依據(jù)。從轉(zhuǎn)運(yùn)體介導(dǎo)和代謝酶介導(dǎo)的中藥相互作用兩方面展開綜述，旨在闡述方劑配伍與藥物代謝的規(guī)律，總結(jié)中藥配伍規(guī)律的內(nèi)在聯(lián)系，探討中藥方劑配伍的科學(xué)性，為闡明中藥方劑作用機(jī)制的科學(xué)內(nèi)涵及其現(xiàn)代配伍研究提供啟示。
[Key word]
[Abstract]
The compatibility of traditional Chinese medicine (TCM) prescription is the basic theory that guides the formulation of TCM and clinical rational drug use, which embodies the medicinal theory and medication method of TCM, representing the characteristics and advantages of TCM. Reasonable prescription compatibility can affect the absorption, distribution, metabolism and excretion of the chemical components in the pharmacokinetic behavior and enhance the efficacy while eliminating or weakening the toxic side effects. Transporters and metabolic enzymes are important components of drug biotransformation. The function changes of transporters and metabolic enzymes caused by the compatibility of TCM are important mechanisms for the changes in the in vivo process of the effective components in the prescriptions. Research on the interaction of TCM based on transporters and metabolic enzymes is one of the important directions to clarify the rules of prescriptions, which helps to show the rules of TCM prescription compatibility and the scientific connotation of TCM toxicity and to provide a scientific basis for the clinical prescription. This article reviews the interaction of TCM mediated by transporters and metabolic enzymes, aiming to elaborate the rules of prescription compatibility and drug metabolism, and summarize the internal relationship in the regulations of TCM prescription compatibility. This article discusses the scientificity of TCM prescription compatibility, so as to provide enlightenment for elucidating the scientific connotation of the mechanism of prescription action and the modern prescription compatibility of TCM.
[中圖分類號(hào)]
R914;R285
[基金項(xiàng)目]
天津市科技計(jì)劃項(xiàng)目（24ZXZSSS00480）;藥物成藥性評(píng)價(jià)與系統(tǒng)轉(zhuǎn)化全國(guó)重點(diǎn)實(shí)驗(yàn)室資助項(xiàng)目（712023001，712023002，712024001）
