目的 探索清咳平喘顆粒治療肺炎支原體肺炎患兒（風(fēng)熱閉肺證、痰熱閉肺證）的臨床有效性及安全性。方法 選取2023年2月—2024年2月在黑龍江中醫(yī)藥大學(xué)附屬第一醫(yī)院、宜興中醫(yī)院、商丘市第一人民醫(yī)院、揚州市中醫(yī)院、北京市房山區(qū)婦幼保健院、許昌市人民醫(yī)院6個中心收治的230例患兒，采用區(qū)組隨機分為對照組112例，治療組118例。對照組采用西醫(yī)基礎(chǔ)治療，治療組在對照組治療的基礎(chǔ)上加服清咳平喘顆粒，比較兩組臨床療效、臨床痊愈時間、臨床癥狀消失時間、體征癥狀積分、炎癥指標、肺功能、肺炎吸收情況及住院天數(shù)。結(jié)果 治療組臨床總有效率（98.31%）顯著高于對照組（92.86%）（P＜0.05），兩組均可顯著改善患兒癥狀、體征積分，降低炎癥因子水平，改善患兒肺功能（P＜0.05），其中治療組的治療作用均顯著強于對照組（P＜0.05）。與對照組相比，治療組可顯著縮短患兒臨床痊愈時間，促進患兒發(fā)熱、咳嗽、咯痰、氣喘、肺部聽診等臨床癥狀消失，提高患兒肺炎吸收評分，縮短住院天數(shù)（P＜0.05）。結(jié)論 清咳平喘顆粒聯(lián)合西醫(yī)常規(guī)治療能夠顯著提高臨床治療的有效率，促進患兒臨床癥狀、體征改善，提高患兒肺功能水平，降低炎癥反應(yīng)，促進肺炎吸收，縮短住院時間，促進疾病轉(zhuǎn)歸，且安全性良好，值得臨床推廣與應(yīng)用。

Objective To explore the clinical efficacy and safety of Qingke Pingchuan Granules (清咳平喘顆粒) in the treatment of children with Mycoplasma pneumoniae pneumonia (wind heat closed lung syndrome, phlegm heat closed lung syndrom). Methods A total of 230 children admitted to the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Yixing Hospital of Traditional Chinese Medicine, Shangqiu First People’s Hospital of Traditional Chinese Medicine, Yangzhou Hospital of Traditional Chinese Medicine, Beijing Fangshan Maternal and Child Health Hospital and Xuchang People’s Hospital from February 2023 to February 2024 were selected and randomly divided into the control group (112 cases) and the treatment group (118 cases). The control group received basic Western medicine treatment, while the treatment group was given Qingke Pingchuan Granules in addition to the control group treatment. The clinical efficacy, clinical recovery time, clinical symptom disappearance time, physical sign symptom score, inflammatory indicators, lung function, pneumonia absorption, and hospitalization days were compared between the two groups. Results The clinical effective rate of the treatment group (98.31%) was significantly higher than that of the control group (92.86%) (P < 0.05). Both groups significantly improved the child patient’s symptom and sign scores, reduced inflammatory factor levels, and improved lung function (P < 0.05). The therapeutic effect of the treatment group was significantly stronger than that of the control group (P < 0.05). In addition, compared with the control group, the treatment group can significantly shorten the clinical recovery time of the children, promote the disappearance of clinical symptoms such as fever, cough, sputum, asthma, and lung auscultation, improve the pneumonia absorption score of the children, and shorten the length of hospital stay (P < 0.05). Conclusion The combination of Qingke Pingchuan Granules and conventional Western medicine treatment can significantly improve the effectiveness of clinical treatment, promote the improvement of clinical symptoms and signs in pediatric patients, improve lung function levels, reduce inflammatory reactions, promote pneumonia absorption, shorten hospitalization time, promote recovery, and have good safety. It is worthy of promotion and application in clinical practice.

R285.64