2型糖尿病（type 2 diabetes mellitus，T2DM）是一種常見的臨床慢性病，近年來肝損傷在T2DM的發(fā)生發(fā)展中備受關(guān)注。持續(xù)性高血糖可導(dǎo)致肝細(xì)胞氧化應(yīng)激和炎癥反應(yīng)，引起脂質(zhì)代謝紊亂與胰島素抵抗。肝臟受損無法有效調(diào)控血糖和脂質(zhì)代謝會(huì)進(jìn)一步加劇全身代謝紊亂。此外，肝細(xì)胞功能障礙影響胰島素降解導(dǎo)致胰島素抵抗進(jìn)一步惡化，加速T2DM的進(jìn)展。中醫(yī)藥憑借其多靶點(diǎn)、多環(huán)節(jié)的作用機(jī)制，不僅能改善肝損傷，還可調(diào)節(jié)糖脂代謝紊亂、調(diào)控炎癥和氧化應(yīng)激反應(yīng)等，在防治T2DM肝損傷中展現(xiàn)出獨(dú)特優(yōu)勢，使其成為防治糖尿病性肝損傷的重要手段。通過對中醫(yī)藥在改善T2DM肝損傷中的機(jī)制進(jìn)行綜述，為提升中醫(yī)藥在T2DM并發(fā)肝損傷治療中的應(yīng)用價(jià)值，為臨床提供更有效的診療策略。

Type 2 diabetes mellitus (T2DM) is a common chronic clinical disease, and liver injury plays a significant role in its development and progression. Persistent hyperglycemia can lead to hepatocellular oxidative stress and inflammatory responses, causing lipid metabolism disorders and insulin resistance. Liver damage impairs the effective regulation of blood glucose and lipid metabolism, further exacerbating systemic metabolic disorders. Additionally, hepatocellular dysfunction affects insulin degradation, leading to worsening insulin resistance and promoting the progression of T2DM. Traditional Chinese medicine (TCM) has demonstrated unique advantages in preventing and treating T2DM-related liver injury through its multi-target and multi-pathway mechanisms. TCM not only improves liver injury but also regulates glucose and lipid metabolism disorders, modulates inflammation and oxidative stress responses, making it an important approach in treating diabetic liver injury. By reviewing the mechanisms of TCM in improving T2DM-related liver injury, this study aims to enhance the application value of TCM in treating T2DM-complicated liver injury and provide more effective diagnostic and therapeutic strategies for patients.

R285

國家自然科學(xué)基金面上項(xiàng)目（82074391）；浙江中醫(yī)藥大學(xué)科研基金人才專項(xiàng)（2021ZR04）