[關(guān)鍵詞]
[摘要]
碳點（carbon dots，CDs）是一種粒徑小于10 nm的新型熒光納米粒子，中藥衍生碳點（carbon dots derived from traditional Chinese medicine，TCM-CDs）是以中藥為前驅(qū)體制備而成的CDs。與傳統(tǒng)CDs相比，TCM-CDs以天然中藥為前驅(qū)體，資源豐富，符合綠色化學(xué)原則；中藥中含有豐富的活性成分賦予了TCM-CDs獨特的藥理活性和生物相容性，有助于藥物遞送和靶向治療，進而可能發(fā)揮更大的藥用價值。TCM-CDs的制備過程成本低廉，適合大規(guī)模應(yīng)用，進一步拓展了其在生物醫(yī)學(xué)領(lǐng)域的潛在價值。由此，近年來TCM-CDs得到了廣泛的關(guān)注和研究。通過詳細介紹TCM-CDs的來源、制備方法及每種制備方法的優(yōu)缺點，系統(tǒng)總結(jié)TCM-CDs的結(jié)構(gòu)特征、性質(zhì)與表征方法，全面綜述TCM-CDs在藥理活性及其機制的最新研究進展，并對TCM-CDs當(dāng)前研究的局限性和未來發(fā)展方向進行了展望，以期推動TCM-CDs在傳統(tǒng)中醫(yī)藥領(lǐng)域的研究應(yīng)用。
[Key word]
[Abstract]
Carbon dots (CDs) are novel fluorescent nanoparticles with a particle size of less than 10 nm. Traditional Chinese medicine (TCM)-derived carbon dots (TCM-CDs) are CDs synthesized using TCM as the precursor. Compared to conventional CDs, TCM-CDs utilize natural TCM resources, which are abundant and align with the principles of green chemistry. The rich active components in TCM endow TCM-CDs with unique pharmacological activities and enhanced biocompatibility, which can facilitate drug delivery and targeted therapy, thus potentially enhancing their medicinal value. Moreover, TCM-CDs are cost-effective to prepare, making them suitable for large-scale applications, which further expands their potential value in the biomedical field. Consequently, TCM-CDs have garnered widespread attention and interest in recent years. This review provides a detailed introduction to the sources and preparation methods of TCM-CDs, along with a discussion of the advantages and disadvantages of each preparation method. It systematically summarizes the structural features, properties, and characterization techniques of TCM-CDs, and comprehensively reviews the latest research progress on the pharmacological activities and mechanisms of TCM-CDs. The review also discusses the current limitations of TCM-CDs research and outlines future development directions, with the aim of promoting the research and application of TCM-CDs in the field of TCM.
[中圖分類號]
R283.3
[基金項目]
江西省研究生創(chuàng)新專項項目（YC2024-B221）；江西中醫(yī)藥大學(xué)校級科技創(chuàng)新團隊發(fā)展計劃（CXTD22007）
