桑白皮是?？浦参锷?i>Morus alba的干燥根皮，其化學(xué)成分主要包括Diels-Alder型加合物、黃酮、茋類、香豆素、生物堿、萜烯和酚酸等，具有降血壓、降血糖、調(diào)血脂、鎮(zhèn)咳、平喘、祛痰、利尿、抗炎、鎮(zhèn)痛、抗病毒、抗腫瘤、抗氧化、護肝和美白等藥理作用。通過基于桑白皮化學(xué)成分和藥理作用的研究進展，從產(chǎn)地、炮制工藝、化學(xué)成分可測性、藥效藥性理論、網(wǎng)絡(luò)藥理學(xué)及入血成分等方面對桑白皮質(zhì)量標志物（quality marker，Q-Marker）進行預(yù)測，初步預(yù)測甜桑皮苷A、桑皮苷C、桑根酮D、桑根酮C、桑辛素、桑黃酮G、桑辛素M、桑辛素D可作為桑白皮Q-Marker，為完善桑白皮量評價體系提供參考。

Sangbaipi (Mori Cortex), derived from the dried root bark of Morus alba (Moraceae family), contains diverse chemical constituents including Diels-Alder adducts, flavonoids, stilbenes, coumarins, alkaloids, terpenes, and phenolic acids. It exhibits comprehensive pharmacological properties encompassing antihypertensive, hypoglycemic, hypolipidemic, antitussive, anti-asthmatic, expectorant, diuretic, anti-inflammatory, analgesic, antiviral, antitumor, antioxidant, hepatoprotective, and skin-whitening effects. This review synthesizes recent advances in the phytochemistry and pharmacodynamics of Mori Cortex to conduct predictive analysis of its quality markers (Q-Markers) through multidimensional evaluation criteria: geographical origin, processing techniques, measurability of chemical constituents, pharmacodynamic and property theories, network pharmacology, and blood-absorbed components. Tentatively proposed Q-Markers candidates include sweet mulberroside A, mulberroside C, sanggenon D, sanggenon C, moracin, kuwanon G, moracin M, and moracin D. These findings provide a scientific foundation for optimizing the quality evaluation system of Mori Cortex, bridging phytochemical characterization with therapeutic efficacy validation in traditional medicine research.

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安徽省高?？蒲许椖?重大項目（2024AH040159）；安徽省高校協(xié)同創(chuàng)新項目（GXXT-2023-073）；亳州職業(yè)技術(shù)學(xué)院第一批“醫(yī)療服務(wù)與保障能力提升補助”專項課題（YLFW1320）