[關(guān)鍵詞]
[摘要]
隨著人口老齡化的加劇,與衰老相關(guān)的疾病發(fā)病率逐漸升高。菟絲子Cuscuta Semen不僅是補益類中藥的代表性藥材,也是抗衰老方劑中出現(xiàn)頻次較高的中藥之一。大量研究發(fā)現(xiàn),菟絲子及其活性成分具有延緩多個靶器官衰老和治療衰老相關(guān)疾病的作用。通過總結(jié)菟絲子不同提取組分及活性成分的抗衰老藥效特征,并進(jìn)一步從衰老相關(guān)的基因組不穩(wěn)定性、細(xì)胞衰老、慢性炎癥、線粒體功能障礙、干細(xì)胞耗竭及自噬功能障礙等生物學(xué)機制,分類梳理菟絲子活性成分延緩衰老的潛在作用機制,為菟絲子在抗衰老領(lǐng)域的臨床應(yīng)用提供參考。
[Key word]
[Abstract]
With the aging of the population, the incidence of aging-related diseases is progressively increasing. Tusizi (Cuscutae Semen), is not only a representative herb in the category of tonic herbs, but also one of the most frequently used herbs in anti-aging formulas. Numerous studies have found that Cuscutae Semen and its active ingredients have the effect of delaying the aging of multiple target organs and treating age-related diseases. By summarizing the anti-aging pharmacological characteristics of different extracts and active components of Cuscutae Semen, and further categorizing and organizing the potential mechanisms of action of its active components in delaying aging based on biological mechanisms such as age-related genomic instability, cellular senescence, chronic inflammation, mitochondrial dysfunction, stem cell depletion, and autophagy dysfunction, this review provides a reference for the clinical application of Cuscutae Semen in the field of anti-aging.
[中圖分類號]
R285
[基金項目]
國家重點研發(fā)計劃項目(2023YFC3504302)