多囊卵巢綜合征（polycystic ovary syndrome，PCOS）是一種常見的生殖內分泌疾病，且臨床異質性高。PCOS的病因尚不清楚，但與遺傳、代謝、內分泌和環(huán)境因素有密切聯(lián)系。迄今為止，還沒有治療PCOS的特異性藥物，PCOS治療策略僅是針對某些癥狀。槲皮素具有抗炎、抗氧化、降低血糖和膽固醇及改善內皮功能等藥理活性。研究發(fā)現(xiàn)，槲皮素能夠通過其生物特性改善PCOS臨床癥狀，如改善肥胖、調節(jié)性激素水平及緩解多囊卵巢形態(tài)等。然而，其確切機制尚未完全闡明。鑒于此，以PCOS的多種病理途徑為切入點，探討槲皮素的作用機制，為臨床應用和藥物開發(fā)提供參考。

Polycystic ovary syndrome (PCOS) is a prevalent reproductive endocrine disease characterized by marked clinical heterogeneity. While the etiology of PCOS remains incompletely understood, it is closely associated with genetic, metabolic, endocrine and environmental factors. To date, no disease-modifying agents specifically targeting PCOS have been established, with current therapeutic strategies focusing solely on symptom management. Quercetin demonstrates multifaceted pharmacological properties including anti-inflammatory, antioxidant, hypoglycemic, and hypocholesterolemic effects, alongside endothelial function improvement. Research has shown that quercetin ameliorates clinical manifestations of PCOS, such as obesity, dysregulated sex hormone profiles, and polycystic ovarian morphology, through its bioactive properties. Nevertheless, the precise mechanistic underpinnings remain incompletely elucidated. Given this, focusing on the diverse pathological pathways implicated in PCOS, this review explores quercetin's mechanisms of action to provide insights for clinical translation and pharmaceutical development.

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黑龍江省卵巢疾病臨床醫(yī)學研究中心（LC2020R009）；國中醫(yī)藥科技中藥便函[2023]24號；黑龍江省中醫(yī)藥學會2022—2024年度青年人才托舉工程項目（2022-QNRC1-02）