[關鍵詞]
[摘要]
隨著環(huán)境與社會因素的改變,患神志疾病的人數逐年增加?,F(xiàn)代醫(yī)學多運用抗精神病藥物治療,但長期服用易出現(xiàn)失眠、頭暈、惡心、自主神經紊亂等不良反應,并且容易產生對藥物的耐藥性。百合Lilii Bulbus作為治療神志疾病的常見藥材,其最早記載于《神農本草經》,主要用于治療陰虛燥咳、虛勞驚悸、失眠多夢等疾病。對百合及其有效化學成分在治療失眠癥、抑郁癥、焦慮癥以及圍絕經期綜合征等神志疾病的研究進行綜述。百合主要通過調節(jié)單胺類神經遞質、改善腸道菌群、調控下丘腦-垂體-腎上腺軸、緩解炎癥及氧化應激等機制,發(fā)揮鎮(zhèn)靜安神的功效,在臨床治療失眠癥、抑郁癥、焦慮癥等神志疾病,具有潛在的研究價值。
[Key word]
[Abstract]
With changes in environmental and social factors, the number of people suffering from psychiatric disorders has been increasing year by year. Modern medicine utilizes antipsychotic drugs for treatment, however, long-term use of antipsychotic drugs can cause various side effects, such as insomnia, dizziness, nausea, autonomic disorders, and other adverse reactions, as well as make the patient resistant to the drugs. As a common medicinal herb for the treatment of psychosomatic diseases, Lilii Bulbus was first recorded in Shennong’ Classic of Materia Medica, and is mainly used for the treatment of yin deficiency and dry cough, palpitations due to deficiency labor, insomnia and excessive dreaming. In this paper, we review the research progress of Lilii Bulbus and its effective chemical components in the treatment of insomnia, depression, anxiety and perimenopausal syndrome and other psychosomatic disorders. By regulating monoamine neurotransmitters, improving intestinal flora, regulating the hypothalamic-pituitary-adrenal axis, and alleviating inflammation and oxidative stress, Lilii Bulbus exerts sedative and tranquilizing effects, which is potentially valuable in the clinical treatment of insomnia, depression, anxiety and other psychiatric disorders.
[中圖分類號]
R285
[基金項目]
國家自然科學基金資助項目(82360896);甘肅省自然科學基金資助項目(24JRRA556);西北營養(yǎng)與環(huán)境相關疾病中醫(yī)藥防控協(xié)同創(chuàng)新中心開放基金課題(ZYXT-24-06)